1........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......
hemo-tunicate-1 -----M--------------------------------P-------------------------------------------------------------F--TDEELKLLRDSWDEVK--KLGM---KEVGLHIFTGLLNAAPSLRTLFYTIDLPD--E--EEL----TIDVMREN-----KKVVAHATRIANAISKFIKFLD---Q-PD---E---LEKLLTS---LGESH-ARRQ---V-DPESFEYVAPVILSVIGGH----L----KLPSNSPTLQAWVKA----YGVLRNGIV-SA--MEA---------------------------------------------------
hemo-tunicate-3 -----M--------------------------------S-------------------------------------------------------------L--TSEQVVLLRSSWQTIG--KLGM---SNVGLAVLHRLFNDVPETLPFFHSVLSP---T--QQT----EIEVLKSN-----AKVVRHASRVGLSIDKIINLLD---N-GE---E---LVKYLLF---LGQVH-VKRS---I-PRKYFSAMGPVLLSVISAV----L----EKDLDAPVMQAWATA----YGVIEQGII-DG--M-----------------------------------------------------
hemo-polychaete-4 -----M--------------------------------G-------------------------------------------------------------L--SAAQRQVVASTWKDIAGSD-NG---AGVGKECFTKFLSAHHDIAAVFG--------F--SGA----S------D-----PGVADLGAKVLAQIGVAVSHLG---D-EG---K---MVAEMKA---VGVRH-KGYGYKHI-KAEYFEPLGASLLSAMEHR----I----GGKMTAAAKDAWAAA----YADISGALI-SG--L--QS-------------------------------------------------
myo-polychaete -----MA-------------------------------G-------------------------------------------------------------L--SGADIAVIRSTWAKVQGSG-SA---TDIGRSIFIKFFELDPAAQNEFP--------C--KGE----SLAALKTN-----VLLGQHGAKFMEYITTAVNGLD---DYAG---K---AHGPLTE---LGSRH-KTRG---T-TPANFGKAGEALLAILASV----V----GGDFTPAAKDAWTKV----YNTISSTMQ-AA--L-----------------------------------------------------
leghemo-pea -----M--------------------------------G-------------------------------------------------------------F--TEKQEALVNSSWELFK--Q-NP---SY-SVLFYTIILKKAPAAKGMFS--------F--LKD----SA-EVVDS-----PKLQAHAEKVFGMVHDSAIQLR---A-SG---E---VVLGDAT---LGAIH-IQKG---V-VDPHFVVVKEALLETIKEA----S----GEKWSEELSTAWEVA----YEGLASAIK-KA--M----N------------------------------------------------
leghemo-rice -----M--------------------------------ALVEDNNAVAVS--------------------------------------------------F--SEEQEALVLKSWAILK--K-DS---ANIALRFFLKIFEVAPSASQMFS--------F--LRN----SDVPLEKN-----PKLKTHAMSVFVMTCEAAAQLR---K-AG---K---VTVRDTTLKRLGATH-LKYG---V-GDAHFEVVKFALLDTIKEE----VP---ADMWSPAMKSAWSEA----YDHLVAAIK-QE--M----KPAE---------------------------------------------
neuro-human -----M-E------------------------------R------------------------------------------------------------------PEPELIRQSWRAVS--R-SP---LEHGTVLFARLFALEPDLLPLFQ--------Y--NCRQFS-SPEDCLSS-----PEFLDHIRKVMLVIDAAVTNVE---D-LS---S---LEEYLAS---LGRKH-RAVG---V-KLSSFSTVGESLLYMLEKC----L----GPAFTPATRAAWSQL----YGAVVQAMS-RG--W----------DGE----------------------------------------
neuro-zebrafish -----M-E------------------------------K-------------------------------------------------------------L--SEKDKGLIRDSWESLG--K-NK---VPHGIVLFTRLFELDPALLTLFS--------YSTNCG----DAPECLSS-----PEFLEHVTKVMLVIDAAVSHLD---D-LH---T---LEDFLLN---LGRKH-QAVG---V-NTQSFALVGESLLYMLQSS----L----GPAYTTSLRQAWLTM----YSIVVSAMT-RG--W--------AKNGEHKSN------------------------------------
HbA-blood_clam -----M--------------------------------A-----------DEEQIAKAVFKEAKA-----------------------------------LCDSDAAKENLRSSFKILA--N-DI---ESSGLQLMKNLFTSHPDTLGYFA------R-F--KDV----SLG--KQN-----WQLRGHAITLMYALMNFVDALD---E-PD---R---LKCVVLK---FAVNH-NNRS---I-SPQVFGKINGPMDLLLKQR----M----GKYYNRETANAWKQL----VGVVQAALT-TP--N-----------------------------------------------------
HbI-Lucina M-------------------------------------S-------------------------------------------------------------L--SAAQKDNVKSSWAKAS--A-AW---GTAGPEFFMALFDAHDDVFAKFS------GLF--KGA----AKGTVKNT-----PEMAAQAQSFKGLVSNWVDNLD---N-AG---A---LEGQCKT---FAANH-KARG---I-SAGQLEAAFKVLAGFMKSY----G----GD------EGAWTAV----AGALMGMIR-PN--M-----------------------------------------------------
HbII-Lucina T-------------------------------------T-------------------------------------------------------------L--TNPQKAAIRSSWSKFM--D-NG---VSNGQGFYMDLFKAHPETLTPFK------SLF--GGL----TLAQLQDN-----PKMKAQSLVFCNGMSSFVDHLD---D--N---M---LVVLIQK---MAKLH-NNRG---I-RASDLRTAYDILIHYMEDHNHMVG----GA------KDAWEVF----VGFICKTLG-DY--M-----------------KELS--------------------------------
myo-Dolabella --------------------------------------A-------------------------------------------------------------L--SAAEAEVVAKSWGPVF--A-NK---DANGDNFLIALFEAYPDSPNFFA------D-F--KGK----SIADIRAS-----PKLRNVSSRIVSRLNEFVSSAA---D-AG---K---MAAMLDQ---FSKEH-AGFG---V-GSQQFQNVSAMFPGFVASI----A----APPAGA--DAAWGKL----FGLIIDAMKKAG--K-----------------------------------------------------
myo-snail --------------------------------------S-------------------------------------------------------------L--QPASKSALASSWKTLA--K-DAATIQNNGATLFSLLFKQFPDTRNYFT------H-F--GNM----SDAEMKTT-----GVGKAHSMAVFAGIGSMIDSMD---D-AD---C---MNGLALK---LSRNH-IQRK---I-GASRFGEMRQVFPNFLDEA----L----GGGASGDVKGAWDAL----LAYLQDNKQAQA--L-----------------------------------------------------
drosophila -----M-------------------------------------------------------------------------------------------------NSDEVQLIKKTWEIPV--A-TP---TDSGAAILTQFFNRFPSNLEKFP--------F--RDV----PLEELSGN-----ARFRAHAGRIIRVFDESIQVLGQDGD-LE---K---LDEIWTK---IAVSH-IPRT---V-SKESYNQLKGVILDVLTAA----C----SLDES--QAATWAKLVDHVYAIIFKAID-DDGNA-----------------------------------------------------
midge-8 -AVTPM-------------------------------------------------------------------------------------------------SADQLALFKSSWNTVK--H-NE-------VDILYAVFKANPDIQAKFP------Q-F--AGK----DLDSIKDS-----ADFAVHSGRIVGFFSEVIGLIG---N-PENRPA---LKTLIDG---LASSH-KARG---I-EKAQFEEFRASLVDYLSHH----L----DWNDT--MKSTWDLALNNMFFYILHALE-VA--Q-----------------------------------------------------
honeybee -----M--GTFLRFLGISSSDDNRIDQAT---------G-------------------------------------------------------------L--TERQKKLVQNTWAVVR--K-DE---VASGIAVMTAFFKKYPEYQRYFT------A-F--MDT----PLNELPAN-----KRFQAHCAGVITALNNVIDFLH---D-PG---L---MEASLIG---LVERH-KKRG---Q-TKEEFQNLKEVMLEVLRQA----L----GKQYTPEVAEAWNKTLDMMFGKIYQVFA-S---------------------------------------------------------
beetle -----M--GQLISLYKYYTTRTDDPDPLT---------T-------------------------------------------------------------L--TSREVFLVQSSWDPIK--K-DL---TGYGVQLLLFLFKKYPEEQQNFP--------F--RDM----PFEELGAS-----KKFHAHCSNVMYAVDSIIDSLK---D-GE---L---LVNILEK---IGRNH-HRNT---V-KPISFWHVKETMLEFFKKM----M--------NDETLKAWDKALQVAFGVVAKELD-KK--N-----------------------------------------------------
cyto-beetle -----M--GIITSTLSYYMTKTNDPDPIT---------G-------------------------------------------------------------L--TSRDRYVIQTSWAPVK--K-DL---TGNGVALLLLYFEKFPATKNYFV--------F--KDV----PNEKLKTD-----KKFHAHCNSVMVTLDSLIANLN---D-GE---L---IVSLLEK---LGKNH-KRHG---I-KDDAYDQLKETVIELFSSF----M--------TKEELETWDKLLKVAFSVIIKYL------------------------------------------------------------
myo-human -----M--------------------------------G-------------------------------------------------------------L--SDGEWQLVLNVWGKVE--A-DI---PGHGQEVLIRLFKGHPETLEKFD------K-F--KHL---KSEDEMKAS-----EDLKKHGATVLTALGGILKK-------------KGHHEAEIKP---LAQSHATKHK---I-PVKYLEFISECIIQVLQSK----H----PGDFGADAQGAMNKA----LELFRKDMA-SN--Y---------------------------------------------KELGFQG-
myo-shark --------------------------------------------------------------------------------------------------V-------DWEKVNSVWSAVE--S-DL---TAIGQNILLRLFEQYPESQNHFP------K-F--KN----KSLGELKDT-----ADIKAQADTVLSALGNIVKK-------------KGSHSQPVKA---LAATHITTHK---I-PPHYFTKITTIAVDVLSEM----Y----PSEMNAQVQAAFSGA----FKIICSDIE-KE--Y---------------------------------------------KAANFQG-
cyto-fish -----M--------------------------------S--------------------------HREPPPPQLAVQRRDVDGQDGPERAEP--------L--SDTEREMIRDAWGHVY--K-NC---EDVGVSILIRFFVNFPSAKQYFS------Q-F--QDM---EEPEEMERS-----SQLRHHACRVMNALNTVVENLH---D-PE---K---VSSVLAV---VGRAHAVKHK---V-EPMYFKILSGVILEVLCED----F----PEFFTADVQLVWSKL----MATVYWHVT-GA--Y---------------------TDVGWLQ-----------VSSSAV--------
cyto-human -----M-------------------------------------------------------------EKVPGEMEIERR--------ERSEE--------L--SEAERKAVQAMWARLY--A-NC---EDVGVAILVRFFVNFPSAKQYFS------Q-F--KHM---EDPLEMERS-----PQLRKHACRVMGALNTVVENLH---D-PD---K---VSSVLAL---VGKAHALKHK---V-EPVYFKILSGVILEVVAEE----F----ASDFPPETQRAWAKL----RGLIYSHVT-AA--Y---------------------KEVGWVQQVPNATTPPATLPSSGP--------
hagfish -----M--------------------------------S-----------------------------------------------------AHGIAR--T--TEGERAAVRASWAVLM--K-DY---EHAGVQILDKFFKANPAAKPFFT------K-M--KDL---HTLEDLASS-----ADARWHVERIIQAVNFAVINIE---D-RE---K---LSNKFVK---LSQDHIEEFH---VTDPQYFMILSQTILDEV---------EKRNGGLSGEGKSGWHKV----MTIICKMLK-SK--Y-----------------------------------------------------
lamprey -----M-----------------------PIVDSGSVPA-------------------------------------------------------------L--TAAEKATIRTAWAPVY--A-KY---QSTGVDILIKFFTSNPAAQAFFP------K-F--QGL---TSADQLKKS-----MDVRWHAERIINAVNDAVVAMD---D-TE---K---MSLKLRE---LSGKHAKSFQ---V-DPQYFKVLAAVIVDTV---------L--PGD------AGLEKL----MSMICILLR-SS--Y-----------------------------------------------------
hemo-alpha-human -----M--------------------------------V-------------------------------------------------------------L--SPADKTNVKAAWGKVG--A-HA---GEYGAEALERMFLSFPTTKTYFP------H-F---DL---SH-----GS-----AQVKGHGKKVADALTNAVAHVD---D----------MPNALSA---LSDLHAHKLR---V-DPVNFKLLSHCLLVTLAAH----L----PAEFTPAVHASLDKF----LASVSTVLT-SK--Y----------------------------------------------------R
hemo-alpha-shark --------------------------------------V-------------------------------------------------------------L--SAADKTAIKHLTGSLR--T-NA---EAWGAESLARMFATTPSTKTYFS------K-F--TDF---SA-----NG-----KRVKAHGGKVLNAVADATDHLD---N----------VAGHLDP---LAVLHGTTLC---V-DPHNFPLLTQCILVTLAAH----L-----TELKPETHCALDKF----LCEVATALG-SH--Y----------------------------------------------------R
hemo-beta-human -----M--------------------------------V------------------------------------------------------------HL--TPEEKSAVTALWGKV-----NV---DEVGGEALGRLLVVYPWTQRFFE------S-F--GDL---STPDAVMGN-----PKVKAHGKKVLGAFSDGLAHLD---N----------LKGTFAT---LSELHCDKLH---V-DPENFRLLGNVLVCVLAHH----F----GKEFTPPVQAAYQKV----VAGVANALA-HK--Y----------------------------------------------------H
hemo-beta-shark --------------------------------------V------------------------------------------------------------HW--TGEEKALVNAVWTKT-----DH---QAVVAKALERLFVVYPWTKTYFV------K-F--NGK------------FHASDSTVQTHAGKVVSALTVAYNHID---D----------VKPHFVE---LSKKHYEELH---V-DPENFKLLANCLEVELGHA----L----HKEFTPEVQAAWSKF----SNVVVDALS-KG--Y----------------------------------------------------H